Wall Street Journal Chemotherapy a Trusty Weapon Agains Cancer

	1. Biologie
Oestrogen causes neuroblastoma cells to mature into neurons [Karolinska Institutet] The female sex activity hormone oestrogen tin can perform an important office in neuroblastoma, a grade of cancer mainly affecting immature children. In laboratory experiments, researchers at Karolinska Institutet demonstrate that oestrogen treatment and overexpression of the oestrogen receptor cause malignant neuroblastoma cells to mature into neuron-like cells.
	one.four Biologie - Technos
Scientists use small-scale device to map human genetic code [Reuters] Using a device about the size of a mobile phone and called a MinION, made by Oxford Nanopore Technologies, researchers from Britain, the United States and Canada said they were able to sequence much longer strands of Dna than previously, making the procedure cheaper and swifter.
Breakthrough leads to sequencing of a human genome using a pocket-sized device [University of Birmingham] A new nanopore technology for direct sequencing of long strands of Dna has resulted in the about complete human genome ever assembled with a single technology, scientists have revealed.
	3.i Prévention - Tabac
American Association for Cancer Research Provides Comments to the FDA on Nicotine Replacement Therapies [AACR] The AACR Tobacco & Cancer Subcommittee recommends improving the appeal and nicotine delivery of NRT to increase uptake and efficacy of these smoking abeyance products.
	3.1.1 Prévention - Tabac - e-cigs
Due east-cigarettes less harmful than conventional cigarettes, merely may lead youth to showtime smoking, says National Academies report [The Cancer Letter] The report, commissioned by FDA at the direction of Congress, is the result of a comprehensive and systematic review of over 800 peer-reviewed studies on e-cigarettes.
Vaping may raise cancer and center disease risk, study suggests [The Guardian] Nicotine in e-cigarettes may convert into DNA-damaging chemicals, mouse trial indicates, but critics say results are irrelevant to humans.
	4.9 Dép., diag. & prono. - Sein
False facts and alternative truths in medical inquiry [BMC Medical Ethics] The objective of this report is to investigate how polarised inquiry produce "polarised facts." Mammography screening for breast cancer is practical every bit an example. A literature search identifies 8 studies publishing results for Overdiagnosis to Mortality Reduction Ratio (OMRR) and reveals that OMRR varies 25-fold, from 0.4 to 10.
	5. Traitements
Chemotherapy, a Trusty Weapon Confronting Cancer, Falls Out of Favor [Wall Street Journal] Chest-cancer doctors are at odds over whether some patients should get less chemo—or none at all.
	5.10 Traitements - Essais
An Unlikely Treatment for Triple-Negative Breast Cancer: Prostate Cancer Drugs [Memorial Sloan Kettering Cancer Center] The contempo JCO report reported results from 78 women with avant-garde triple-negative chest cancer that expressed the androgen receptor. The purpose of the phase 2 trial was to evaluate the prophylactic and efficacy of the prostate cancer drug enzalutamide (Xtandi®).
	5.12 Immunothérapies
Kiss-and-tell manner to rail cell contacts [Nature] The authors refer to this method of tracking a molecular 'kiss' betwixt cells equally LIPSTIC.
	5.12.9 Immunothérapies - SITC
Immuno-Oncology Conference Features Checkpoints, Car-Ts and More [Cancer Health] This new way of looking at cancer could too be challenging for patient back up and advocacy groups, which have traditionally been organized by cancer blazon.
	5.2.one Pharma - Partenariats
Innate Pharma and MedImmune enter clinical trial collaboration [Innate Pharma] Innate Pharma and MedImmune will evaluate the combination of Innate Pharma's get-go-in-class IPH5401 antibody and Imfinzi® (durvalumab) in a Phase I/Two written report for patients with selected solid tumors.
	5.2.2 Pharma - Fusions & Acquisitions
Sanofi CEO: $xvi Billion Bargain Binge Does Not Represent A Change In Strategy [Forbes] Today's purchase of Ablynx NV, a Belgium-based biotech firm, for $iv.8 billion and terminal week's decision to buy Bioverativ, a U.Southward. firm focused on hemophilia, for $11.half dozen billion both met a stringent fix of criteria: they had to be strategic, plumbing equipment Brandicourt's strategy in both cases of betting on rare diseases where treatments tin accept higher prices, a return on capital in a matter of iii to five years, and, if possible, be accretive to earnings.
	5.iii Traitements - FDA, EMA, NICE...
Statement by Executive Managing director Guido Rasi in The Hague [EMA] At that place is nevertheless another layer of complication: EMA's final building in Amsterdam will not be ready by then, so we will demand to first motion to temporary bounds in the city, and so to the final edifice. This double transfer volition force us to invest more than resources.
	five.3.4 Traitements - AMM (FDA, EMA,...)
Olaparib Canonical for Treating Some Breast Cancers with BRCA Factor Mutations [NCI] The primary endpoint of the trial—which was funded past olaparib'south manufacturer, AstraZeneca—was progression-free survival. In the report, median progression-free survival was 7.0 months for patients in the olaparib group compared with 4.2 months for patients in the standard-therapy group.
	5.4 Traitements - Economie
Trump says new wellness secretary will 'get those prescription prices mode downward' [STAT] Azar comes to the authorities from the drug visitor Eli Lilly — which itself is the target of scrutiny for raising the price of insulin. Exactly what Azar and Trump volition exercise remains unclear.
New Cancer Drugs Fund benefiting thousands of patients and releasing £140million for the NHS [NHS England] Since the new CDF opened in July 2016, most 15,700 patients have benefited from the 52 drugs treating 81 different types of cancer. Of these patients, around 5,000 have received treatment sooner than they would have nether the previous arrangement.
	half dozen. Lutte contre les cancers
Upcoming Symposium to Characteristic New Research on Concrete Action, Sexual Aids, Follow-Up Care for Cancer Survivors [ASCO] Abstracts presented at the Symposium will focus on efforts to better understand the needs of millions of cancer survivors worldwide, and to develop comprehensive care models that meet those needs.
	vi.ten Politiques
Brexit Wellness Alliance warns of UK at back of the medicine queue [Pharmafile] The written report used the examples of Switzerland, Australia and Canada, equally providing examples of countries that have struggled to concenter new medicine applications prior to large markets, such as the US and the European union.
	6.three Associations/Fondations
Gary Reedy describes plan for turning around the American Cancer Society [The Cancer Letter] Reedy is a pharma industry guy. He came up through SmithKline Beecham, Centocor, and J&J. Subsequently 37 years in pharma jobs, he is accustomed to cranking out tangible results, aggressive sales quotas, quantifiable targets, aggressive strategies.
	vi.4 Médico-éco
Preventive Care Saves Money? Lamentable, It's Too Good to Be True [NY Times] Contrary to conventional wisdom, it tends to toll coin, but it improves quality of life at a very reasonable price.
	vi.6 Publications
Fixing Instead of Breaking, Office 1 — Open Citations [The Scholarly Kitchen] With so much broken by the Internet, nosotros may be moving into a mode of fixing things. Are open up citations part of the solution, or more of the problem?
	half-dozen.seven DMP, Big Information & applis
Why Apple will succeed where other tech giants have failed: Helping people rail their wellness info [CNBC] The wellness-technology landscape has dramatically changed. X years agone, when Microsoft and Google were battling to make the personal wellness record idea resonate with consumers, much of the basic infrastructure needed to spur adoption did not exist.
	6.8 Communication
Men can get breast cancer too. Let'due south add blue to the pinkish ribbon [The Telegraph] Men who one time would take hidden their diagnosis abroad are now as determined to raise awareness and fight for their correct to handling as their female peers. Mayhap one-half the pink ribbon should be blue – equally is starting time to be seen in the United states.

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Source: http://onco-actu.e-cancer.fr/2018/01/